The Librarian

Erythropoietin and iron supplements have been used for 30 years to treat anemia in patients with chronic kidney disease, but erythropoiesis-stimulating agents can only be safely used to increase hemoglobin levels to 11 g per deciliter. Roxadustat, a member of a new class of drugs called hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors, stimulates erythropoiesis and regulates iron metabolism. As reported in The New England Journal of Medicine, results from two Phase 3 randomized, clinical trials in China suggest that roxadustat may be beneficial for patients with chronic kidney disease. During the 26-week trials, 154 patients with chronic kidney disease not receiving dialysis and 305 patients undergoing long-term dialysis were randomized to receive either roxadustat or epoetin alfa (or a placebo for patients not receiving dialysis). Hemoglobin levels increased and hepcidin levels decreased in both groups of patients receiving roxadustat. Furthermore, roxadustat increased transferrin levels while maintaining serum iron levels and attenuated decreases in transferrin saturation levels. However, patients taking roxadustat were more likely to have hyperkalemia and upper respiratory infections. Allowing hemoglobin levels to be normalized, roxadustat may transform the treatment of chronic kidney disease. Ongoing clinical trials are monitoring roxadustat’s use over longer periods and in other populations. References: Chen N, Hao C, Peng X, Lin H, et al. Roxadustat for anemia in patients with kidney disease not receiving dialysis. The New England Journal of Medicine 2019 Chen N, Hao C, Liu BC, Lin H, et al. Roxadustat treatment for anemia in patients undergoing long-term dialysis. The New England Journal of Medicine 2019 Kaplan J. Roxadustat and anemia of chronic kidney disease. The New England Journal of Medicine 2019

Soon we will have to ditch the business suit since it is becoming fashion relegated to lawyers, courthouses etc... The most common "business suit' now is Khakis .... I won't even mention the IT world.

The first time I have heard this. Interesting thought.

Oh wow... this topic is still alive! ..... interesting.

Here is another version for y'all 2019 - RC Love Never Fails - Notebook.pdf

@BillyTheKid46 I have deleted his threatening message. @JOHN BUTLER I believe you were referring to angels doing the killing at some time in the future and not inciting others to harm anyone. Either way, both of you need to tone it down or I will block you both.

So.... what happens if your thought isn't the same as Mr. Xi?

But would they then share that data with my health insurance plan? Would my rates go up by how many times a month I order fries?

I don't think we are supposed to refer to him as "Ex-President" either.... not sure about that.

Good to know....

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They do sorta have a point don't they?