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The hotter our body temperature, the more our bodies speed up a key defense system that fights against tumors, wounds or infections Date: May 21, 2018 Source: University of Warwick Summary: The hotter our body temperature, the more our bodies speed up a key defense system that fights against tumors, wounds or infections, new research has found. The hotter our body temperature, the more our bodies speed up a key defence system that fights against tumours, wounds or infections, new research by a multidisciplinary team of mathematicians and biologists from the Universities of Warwick and Manchester has found. The researchers have demonstrated that small rises in temperature (such as during a fever) speed up the speed of a cellular 'clock' that controls the response to infections -- and this new understanding could lead to more effective and fast-working drugs which target a key protein involved in this process. Biologists found that inflammatory signals activate 'Nuclear Factor kappa B' (NF-κB) proteins to start a 'clock' ticking, in which NF-κB proteins move backwards and forwards into and out of the cell nucleus, where they switch genes on and off. https://www.sciencedaily.com/releases/2018/05/180521095606.htm