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  1. MONDAY, April 18, 2016 (HealthDay News) -- Sticking to a moderate or intense exercise regimen may improve a man's odds of surviving prostate cancer, a new study suggests. The American Cancer Society study included more than 10,000 men, aged 50 to 93, who were diagnosed between 1992 and 2011 with localized prostate cancer -- meaning it had not spread beyond the gland. The men provided researchers with information about their physical activity before and after their diagnosis. Men with the highest levels of exercise before their diagnosis were 30 percent less likely to die of their prostate cancer than those who exercised the least, according to a team led by Ying Wang, senior epidemiologist at the cancer society's epidemiology research program. More exercise seemed to confer an even bigger benefit: Men with the highest levels of exercise after diagnosis were 34 percent less likely to die of prostate cancer than those who did the least exercise, the study found. The findings were to be presented Monday at the annual meeting of the American Association for Cancer Research, in New Orleans. While the study couldn't prove cause-and-effect, "our results support evidence that prostate cancer survivors should adhere to physical activity guidelines, and suggest that physicians should consider promoting a physically active lifestyle to their prostate cancer patients," Wang said in an AACR news release. The researchers also examined the effects of walking as the only form of exercise. They found that walking for four to six hours a week before diagnosis was also associated with a one-third lower risk of death from prostate cancer. But timing was key, since walking aftera diagnosis was not associated with a statistically significant lower risk of death, the study authors said. "The American Cancer Society recommends adults engage in a minimum of 150 minutes of moderate or 75 minutes of vigorous physical activity per week," Wang said, and "these results indicate that following these guidelines might be associated with better prognosis." Two experts in prostate cancer care said the findings shouldn't come as a big surprise. "Physical activity helps all aspects of health," said Dr. Elizabeth Kavaler, a urology specialist at Lenox Hill Hospital in New York City. "This study reinforces that a healthy lifestyle, including exercise, is one of the few aspects of post-cancer outcome that a patient can control." Dr. Manish Vira, of Northwell Health's Smith Institute for Urology, in New Hyde Park, N.Y., agreed. The study "adds to the growing body of evidence that regular exercise is associated with better prostate cancer outcomes," he said. "Multiple studies have shown improvements in other cancers as well, including breast, colon and lung cancer." "Regular exercise improves patients' cardiovascular health, quality of life, and likely, their overall ability to fight disease," Vira added. Wang stressed that further research is needed to see if the findings might differ by patient age at diagnosis, weight or smoking. More information The U.S. National Cancer Institute has more about prostate cancer. SOURCES: Elizabeth Kavaler, M.D., urology specialist, Lenox Hill Hospital, New York City; Manish Vira, M.D., vice chair, urologic research, Northwell Health's The Arthur Smith Institute for Urology, New Hyde Park, N.Y.; American Association for Cancer Research, news release, April 18, 2016 Source: http://consumer.healthday.com/cancer-information-5/prostate-cancer-news-106/regular-exercise-may-boost-prostate-cancer-survival-709962.html
  2. Study says drug blocks enzymes involved in growth of cancerous tumours Group of 13,000 cardiac patients focus of the research by Italian scientists Nearly 50,000 new cases of prostate cancer every year and 11,000 deaths Aspirin is already taken by millions of Britons with heart disease, but now it seems it may also protect men with heart trouble from prostate cancer. A study of more than 13,000 cardiac patients showed that men taking aspirin had substantially lower levels of prostate cancer than those who did not take it. Overall, they were 36 per cent less likely to get the disease – and among those who had been taking aspirin regularly for five or more years, the likelihood of the disease dropped by an astonishing 57 per cent. A spokesman for the Italian team that carried out the study said: ‘Our findings indicate that low-dose aspirin might be associated with a reduction of risk of prostate cancer in patients with cardio or cerebrovascular [stroke causing] diseases. ‘Raising patients’ awareness of its beneficial role in the prevention of prostate cancer might help improve adherence to the long-term therapy for the prevention of vascular problems.’ Aspirin, a painkiller and anti-inflammatory, is widely prescribed to people at risk of heart disease. In patients whose blood vessels are narrowed from atherosclerosis, or ‘furring’ of the arteries, fatty deposits on the lining can cause a blocked artery and a heart attack. Aspirin works by interfering with blood clotting by reducing the clumping together of platelets or clotting cells. Studies have also suggested it may help prevent colorectal cancers in heart patients. One theory about its anti-cancer effect is that the drug blocks cyclooxygenase or COX enzymes which are involved in the pain and inflammatory process. COX enzymes may also be involved in the growth of new blood vessels that help cancerous tumours to grow, and that by blocking their activity, aspirin reduces the likelihood of the cancer both growing and also spreading. Aspirin may trigger cancer cell death too. There are nearly 50,000 new cases of prostate cancer a year and 11,000 deaths, according to Cancer Research UK. Almost nine out of ten men diagnosed with prostate cancer survive the disease for five years or more. The prostate study was carried out by doctors from the Italian College of General Practitioners and Primary Care and reported in the International Journal Of Cancer. Source: http://www.dailymail.co.uk/health/article-3478085/Prostate-cancer-kept-bay-aspirin-Chance-getting-disease-dropped-half-regularly-use-drug.html
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