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https://www.independent.co.uk/life-style/gadgets-and-tech/anti-ageing-reverse-treatment-telomeres-b1748067.html
Maybe I misunderstood but it appears they they “withheld” some oxygen for 90 minutes per day? Which seems counterintuitive to me.
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A Harvard team has discovered a set of small molecules capable of restoring telomere length in mice.By Health and Medicine
Hello guest! Please register or sign in (it's free) to view the hidden content. "...the team used human blood stem cells and triggered mutations in the PARN gene that give rise to dyskeratosis congenita. These were then implanted into mice that were treated with the compounds, with the team finding the treatment boosted TERC, restored telomere length in the stem cells and had no ill effects on the rodents.
“This provided the hope that this could become a clinical treatment,” says Nagpal.
The team will now continue its work in an effort to prove these small molecules are a safe and effective way to apply the brakes to dyskeratosis congenita, other diseases, and possibly aging more broadly.
“We envision these to be a new class of oral medicines that target stem cells throughout the body,” Agarwal says. “We expect restoring telomeres in stem cells will increase tissue regenerative capacity in the blood, lungs, and other organs affected in DC and other diseases.”
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By Jack Ryan
Hello guest! Please register or sign in (it's free) to view the hidden content. Alamosa resident dead, arrest warrant issued for husband
By: Ruth Heide - Updated: 21 hours ago
Recent news, here:
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By Guest Nicole
Date:
August 2, 2017
Source:
Florida Atlantic University
Summary:
Restricting how much you eat without starving has been shown to robustly extend lifespan in more than 20 species of animals including primates. How this works is still unclear. A new study shows that it's not just what or how much you eat that matters. Smelling food in addition to consuming calories could influence the aging process. And, what's 'eating' you or more specifically your cells may provide clues to healthy aging.
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By Guest Nicole
Meals from the sunny Mediterranean have been linked to stronger bones, a healthier heart and longer life, along with a reduced risk for diabetes and high blood pressure.
Now you can add lowering your risk for dementia to the ever growing list of reasons to follow the Mediterranean diet or one of its dietary cousins.
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By Guest Nicole
New research shows a major advantage for those who are highly active
Date:
May 10, 2017
Source:
Brigham Young University
Summary:
Despite their best efforts, no scientist has ever come close to stopping humans from aging. Even anti-aging creams can't stop Old Father Time. But new research reveals you may be able to slow one type of aging -- the kind that happens inside your cells. As long as you're willing to sweat.
Despite their best efforts, no scientist has ever come close to stopping humans from aging. Even anti-aging creams can't stop Old Father Time.
But new research from Brigham Young University reveals you may be able to slow one type of aging -- the kind that happens inside your cells. As long as you're willing to sweat.
"Just because you're 40, doesn't mean you're 40 years old biologically," Tucker said. "We all know people that seem younger than their actual age. The more physically active we are, the less biological aging takes place in our bodies."
The study, published in the medical journal Preventive Medicine, finds that people who have consistently high levels of physical activity have significantly longer telomeres than those who have sedentary lifestyles, as well as those who are moderately active.
Telomeres are the protein endcaps of our chromosomes. They're like our biological clock and they're extremely correlated with age; each time a cell replicates, we lose a tiny bit of the endcaps. Therefore, the older we get, the shorter our telomeres.
Exercise science professor Larry Tucker found adults with high physical activity levels have telomeres with a biological aging advantage of nine years over those who are sedentary, and a seven-year advantage compared to those who are moderately active. To be highly active, women had to engage in 30 minutes of jogging per day (40 minutes for men), five days a week.
"If you want to see a real difference in slowing your biological aging, it appears that a little exercise won't cut it," Tucker said. "You have to work out regularly at high levels."
Tucker analyzed data from 5,823 adults who participated in the CDC's National Health and Nutrition Examination Survey, one of the few indexes that includes telomere length values for study subjects. The index also includes data for 62 activities participants might have engaged in over a 30-day window, which Tucker analyzed to calculate levels of physical activity.
His study found the shortest telomeres came from sedentary people -- they had 140 base pairs of DNA less at the end of their telomeres than highly active folks. Surprisingly, he also found there was no significant difference in telomere length between those with low or moderate physical activity and the sedentary people.
Although the exact mechanism for how exercise preserves telomeres is unknown, Tucker said it may be tied to inflammation and oxidative stress. Previous studies have shown telomere length is closely related to those two factors and it is known that exercise can suppress inflammation and oxidative stress over time.
"We know that regular physical activity helps to reduce mortality and prolong life, and now we know part of that advantage may be due to the preservation of telomeres," Tucker said.
Story Source:
Materials provided by Brigham Young University. Note: Content may be edited for style and length.
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By Guest Nicole
Your morning cup of joe may have effects that reach beyond getting you alert and ready for the day. Researchers at Indiana University identified 24compounds that can increase the brain’s production of an enzyme that could help protect it against diseases like Alzheimer’s and other forms of dementia. One of the strongest impacts on the enzyme came from caffeine, which was additionally shown to improve memory function in mice.
The enzyme, called NMNAT2, has a protective effect on the brain. Researchers previously found that the enzyme has two important functions - it can guard neurons from stress and work as a “chaperone” when it fights against misfolded proteins called tau which form age-related “plaques.”
The misfolded tau proteins are related to a host of neurogenerative diseases like Parkinson’s, Alzheimer’s and Huntington’s as well as Lou Gehrig’s disease or ALS.
"This work could help advance efforts to develop drugs that increase levels of this enzyme in the brain, creating a chemical 'blockade' against the debilitating effects of neurodegenerative disorders," said Professor Hui-Chen Lu, who led the study.
Researchers went through 1,280 compounds, which included current drugs, in an effort to figure out what can influence the production of the NMNAT2 enzyme. Besides caffeine, the world's most popular drug, scientists found that a discontinued anti-depressant drug rolipram also gives a strong boost to the helpful enzyme’s production. Other compounds that have a weaker effect on increasing the amount of NMNAT2 include ziprasidone, canthardin, wortmannin and retonoic acid (found in vitamin A).
The scientists are excited about identifying the compounds, hoping they will lead to an increase in our overall understanding of what happens in the brain due to the brain disorders. They also found 13 compounds that lower the protective enzyme.
"Increasing our knowledge about the pathways in the brain that appear to naturally cause the decline of this necessary protein is equally as important as identifying compounds that could play a role in future treatment of these debilitating mental disorders," said Lu.
The study was published in the journal Scientific Reports.
Cover photo: A young woman samples freshly-brewed cappuccino at Bonanza Coffee Roasters on January 24, 2011 in Berlin, Germany. (Photo by Sean Gallup/Getty Images)
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By Guest Nicole
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By Guest Nicole
In lots of measurable ways, life gets better as you get older: Studies indicate that people get more agreeable and conscientious and trusting as they age, and having survived the ravages of time, they gain in wisdom, too. Especially, according to a new paper, in bed.
Published in the Journal of Sexual Research, a research team led by University of Minnesota postdoc Miri Forbes analyzed data on 6,000 people aged 20 to 93. The responses were survey questions completed by mail in 1995, 2003, and 2013.
As Forbes and her colleagues note in a new post about their research at the Conversation, people’s outlook on sex shifted as they got older — caring more about the “thought and effort” put into sexuality, and less hung up on frequency of getting laid. That change in priorities was a big predictor of older people’s sex-life satisfaction, they found.
“When we matched older and younger adults on key characteristics of their sex lives — along with socio-demographic characteristics, and mental and physical health — older adults actually had better sexual quality of life” than younger adults, the authors write.
This was especially true for people in long-term romantic relationships: Consistent with earlier studies showing that stability was related to being more adventurous and attentive to a partner, which is, as another sexuality researcher told Science of Us, the one true way to get better at sex. Forbes and her team call it “sexual wisdom.”
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By Guest Nicole
FRIDAY, Aug. 26, 2016 (HealthDay News) -- Couch potatoes have a higher risk of developing dementia in old age, a new study reports.
Seniors who get little to no exercise have a 50 percent greater risk of dementia compared with those who regularly take part in moderate or heavy amounts of physical activity, the researchers found.
Moderate physical activity can include walking briskly, bicycling slower than 10 miles an hour, ballroom dancing or gardening, according to the U.S. Centers for Disease Control and Prevention.
"It doesn't require intensive physical activity to decrease risk of dementia," said senior researcher Dr. Zaldy Tan. He is medical director of the Alzheimer's and Dementia Care Program at University of California, Los Angeles. "Even moderate amounts are fine."
Study participants aged 75 or older gained the most protective benefit from exercise against the onset of dementia, the findings showed.
"The message here is that you're never too old to exercise and gain benefit from it," Tan said. "These patients derive the most benefit from exercise because they are the ones who are at the age of greatest risk for dementia."
Brain scans of participants showed those who exercise are better able to withstand the effects of aging on the brain, the study authors said.
With age, the brain tends to shrink. But people who regularly exercised tended to have larger brain volumes than those who were sedentary, Tan and his colleagues found.
The new study involved about 3,700 participants in the Framingham Heart Study, a federally funded health research project begun in 1948. All were 60 and older.
Researchers measured how often the participants exercised, and tracked them over a decade. During the study, 236 people developed dementia.
To see how physical activity might have affected dementia risk, the researchers broke the study population down into fifths that ranged from sedentary to highly active.
The one-fifth containing the most sedentary people were 50 percent more likely to develop dementia than the other four-fifths, the investigators found. In other words, even a little exercise helped.
The research team also compared physical activity to brain scans taken of about 2,000 study participants, and found a direct connection between exercise and brain size as people aged. Those who worked out had more total brain volume.
There are several theories why exercise might help brain health. Increased blood flow caused by physical activity might "beef up" the brain, increasing its volume and promoting the growth of additional neurons, said Dr. Malaz Boustani. He is research director of the Healthy Aging Brain Center at the Indiana University Center for Aging Research and a spokesman for the American Federation for Aging Research.
"Physical exercise might end up leading to increased density of the connections between the neurons and create alternative pathways for signals" that might otherwise be impeded due to age-related brain shrinkage, he added.
Boustani likened this process to a street system in a city. The more alternative routes are available to drivers, the less likely it is that a blockage on one street will lead to a city-wide traffic jam.
Exercise also promotes secretion of helpful brain chemicals such as brain-derived neurotrophic factor (BDNF). Tan explained that "BDNF actually encourages the growth of new neurons, and the preservation of those we already have."
Heather Snyder, senior director of medical and scientific operations for the Alzheimer's Association, said that the true answer is likely a combination of factors related to exercise.
"It's likely there are multiple benefits, and they all funnel together," Snyder said.
According to Boustani, these results support other studies that have shown an association between exercise and protection against dementia, but clinical trials aimed at proving a definite link have so far been disappointing.
"When we take it to the next step and start doing experiments, randomizing patients to physical exercise versus no physical exercise and see if that will protect their brain, the story becomes a little bit muddy and unclear," he said.
Regardless, Boustani said he prescribes moderate intensity physical exercise to his patients as one way to preserve their brain health -- 5,000 steps a day for about a month, increasing to 10,000 steps over time.
"Given that there's no harm, and there's a possible benefit to the brain that hasn't been fully explained, I work with my patients and their families to help improve their physical activity," he said.
The findings were published online recently in Journals of Gerontology: Medical Sciences.
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