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Nicole

Why Sitting May Be Bad for Your Brain

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Sitting for hours without moving can slow the flow of blood to our brains, according to a cautionary new study of office workers, a finding that could have implications for long-term brain health. But getting up and strolling for just two minutes every half-hour seems to stave off this decline in brain blood flow and may even increase it.

Delivering blood to our brains is one of those automatic internal processes that most of us seldom consider, although it is essential for life and cognition. Brain cells need the oxygen and nutrients that blood contains, and several large arteries constantly shuttle blood up to our skulls.

Because this flow is so necessary, the brain tightly regulates it, tracking a variety of physiological signals, including the levels of carbon dioxide in our blood, to keep the flow rate within a very narrow range.

Read more: https://www.nytimes.com/2018/08/15/well/move/why-sitting-may-be-bad-for-your-brain.html?rref=collection%2Fsectioncollection%2Fhealth

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There is a saying to schoolchildren that they "need to warm up a chair" while learning, it means sitting and learning long. According to this study, the students (and we all) should sit for a shorter time :)))) ( but school hour is 45 minutes in Croatia) 

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"Past studies in people and animals indicate that slight, short-term drops in brain blood flow can temporarily cloud thinking and memory, while longer-term declines are linked to higher risks for some neurodegenerative diseases, including dementia."

uppsssss, some signs are already here

:))))

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      Credit: © pathdoc / Fotolia
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      Story Source:
      Materials provided by University College London. Note: Content may be edited for style and length.
      Journal Reference:
      Neil Garrett, Stephanie C Lazzaro, Dan Ariely, Tali Sharot. The brain adapts to dishonesty. Nature Neuroscience, 2016; DOI: 10.1038/nn.4426
      Cite This Page:
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      University College London. "How lying takes our brains down a 'slippery slope': Telling small lies desensitizes our brains to the associated negative emotions and may encourage us to tell bigger lies in future." ScienceDaily. ScienceDaily, 24 October 2016. <www.sciencedaily.com/releases/2016/10/161024134012.htm>.
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      MRI scans found infants who drank more of it had more brain tissue, study found.
      TUESDAY, May 3, 2016 (HealthDay News) -- Breast milk may help promote brain growth in premature infants, a new study found.
      "The brains of babies born before their due dates usually are not fully developed," explained senior investigator Dr. Cynthia Rogers, an assistant professor of child psychiatry at Washington University in St. Louis.
      "But breast milk has been shown to be helpful in other areas of development, so we looked to see what effect it might have on the brain," Rogers said in a university news release.
      "With MRI scans, we found that babies fed more breast milk had larger brain volumes. This is important because several other studies have shown a correlation between brain volume and cognitive development," she said.
      The study included 77 infants born at least 10 weeks early, with the average being 14 weeks premature. Brain scans were conducted on the infants at about the time when they would have been born if delivered at full term.
      The scans revealed that infants whose daily diets included at least 50 percent breast milk had more brain tissue and cortical-surface area than those who received much less breast milk.
      The findings were to be presented Tuesday at the Pediatric Academic Societies annual meeting, in Baltimore. Research presented at meetings is considered preliminary until published in a peer-reviewed journal.
      Source: https://consumer.healthday.com/women-s-health-information-34/breast-feeding-news-82/preemies-brains-get-a-boost-from-breast-milk-study-shows-710484.html
    • By Nicole
      Scientists report that diet rich in omega-3 fatty acids can reverse the damage
      Date:
      April 22, 2016
      Source:
      University of California - Los Angeles
      Summary:
      Consuming fructose, a sugar that's common in the Western diet, alters hundreds of genes that may be linked to many diseases, life scientists report. However, they discovered good news as well: an important omega-3 fatty acid known as DHA seems to reverse the harmful changes produced by fructose.
       
      A range of diseases -- from diabetes to cardiovascular disease, and from Alzheimer's disease to attention deficit hyperactivity disorder -- are linked to changes to genes in the brain. A new study by UCLA life scientists has found that hundreds of those genes can be damaged by fructose, a sugar that's common in the Western diet, in a way that could lead to those diseases.
      However, the researchers discovered good news as well: An omega-3 fatty acid known as docosahexaenoic acid, or DHA, seems to reverse the harmful changes produced by fructose.
      "DHA changes not just one or two genes; it seems to push the entire gene pattern back to normal, which is remarkable," said Xia Yang, a senior author of the study and a UCLA assistant professor of integrative biology and physiology. "And we can see why it has such a powerful effect."
      DHA occurs naturally in the membranes of our brain cells, but not in a large enough quantity to help fight diseases.
      "The brain and the body are deficient in the machinery to make DHA; it has to come through our diet," said Fernando Gomez-Pinilla, a UCLA professor of neurosurgery and of integrative biology and physiology, and co-senior author of the paper.
      DHA strengthens synapses in the brain and enhances learning and memory. It is abundant in wild salmon (but not in farmed salmon) and, to a lesser extent, in other fish and fish oil, as well as walnuts, flaxseed, and fruits and vegetables, said Gomez-Pinilla, who also is a member of UCLA's Brain Injury Research Center.
      Americans get most of their fructose in foods that are sweetened with high-fructose corn syrup, an inexpensive liquid sweetener made from corn starch, and from sweetened drinks, syrups, honey and desserts. The Department of Agriculture estimates that Americans consumed an average of about 27 pounds of high-fructose corn syrup in 2014. Fructose is also found is in most baby food and in fruit, although the fiber in fruit substantially slows the body's absorption of the sugar -- and fruit contains other healthy components that protect the brain and body, Yang said.
      To test the effects of fructose and DHA, the researchers trained rats to escape from a maze, and then randomly divided the animals into three groups. For the next six weeks, one group of rats drank water with an amount of fructose that would be roughly equivalent to a person drinking a liter of soda per day. The second group was given fructose water and a diet rich in DHA. The third received water without fructose and no DHA.
      After the six weeks, the rats were put through the maze again. The animals that had been given only the fructose navigated the maze about half as fast than the rats that drank only water -- indicating that the fructose diet had impaired their memory. The rats that had been given fructose and DHA, however, showed very similar results to those that only drank water -- which strongly suggests that the DHA eliminated fructose's harmful effects.
      Other tests on the rats revealed more major differences: The rats receiving a high-fructose diet had much higher blood glucose, triglycerides and insulin levels than the other two groups. Those results are significant because in humans, elevated glucose, triglycerides and insulin are linked to obesity, diabetes and many other diseases.
      The research team sequenced more than 20,000 genes in the rats' brains, and identified more than 700 genes in the hypothalamus (the brain's major metabolic control center) and more than 200 genes in the hippocampus (which helps regulate learning and memory) that were altered by the fructose. The altered genes they identified, the vast majority of which are comparable to genes in humans, are among those that interact to regulate metabolism, cell communication and inflammation. Among the conditions that can be caused by alterations to those genes are Parkinson's disease, depression, bipolar disorder, and other brain diseases, said Yang, who also is a member of UCLA's Institute for Quantitative and Computational Biosciences.
      Of the 900 genes they identified, the researchers found that two in particular, called Bgn and Fmod, appear to be among the first genes in the brain that are affected by fructose. Once those genes are altered, they can set off a cascade effect that eventually alters hundreds of others, Yang said.
      That could mean that Bgn and Fmod would be potential targets for new drugs to treat diseases that are caused by altered genes in the brain, she added.
      The research also uncovered new details about the mechanism fructose uses to disrupt genes. The scientists found that fructose removes or adds a biochemical group to cytosine, one of the four nucleotides that make up DNA. (The others are adenine, thymine and guanine.) This type of modification plays a critical role in turning genes "on" or "off."
      The research is published online in EBioMedicine, a journal published jointly by Cell and The Lancet. It is the first genomics study of all the genes, pathways and gene networks affected by fructose consumption in the regions of the brain that control metabolism and brain function.
      Previous research led by Gomez-Pinilla found that fructose damages communication between brain cells and increases toxic molecules in the brain; and that a long-term high-fructose diet diminishes the brain's ability to learn and remember information.
      "Food is like a pharmaceutical compound that affects the brain," said Gomez-Pinilla. He recommends avoiding sugary soft drinks, cutting down on desserts and generally consuming less sugar and saturated fat.
      Although DHA appears to be quite beneficial, Yang said it is not a magic bullet for curing diseases. Additional research will be needed to determine the extent of its ability to reverse damage to human genes.
      The paper's lead author is Qingying Meng, a postdoctoral scholar in Yang's laboratory. Other co-authors are Zhe Ying, a staff research associate in Gomez-Pinilla's laboratory, and colleagues from UCLA, the National Institutes of Health and Icahn School of Medicine at Mount Sinai in New York.
      Yang's research is supported by the National Institutes of Health (grant R01DK104363), as is Gomez-Pinilla's (R01DK104363 and R01NS050465).
      Story Source:
      The above post is reprinted from materials provided by University of California - Los Angeles. Note: Materials may be edited for content and length.
      Source: https://www.sciencedaily.com/releases/2016/04/160422091900.htm

      Americans get most of their fructose in foods that are sweetened with high-fructose corn syrup, an inexpensive liquid sweetener made from corn starch, and from sweetened drinks, syrups, honey and desserts. The Department of Agriculture estimates that Americans consumed an average of about 27 pounds of high-fructose corn syrup in 2014.
      Credit: © AlenKadr / Fotolia
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