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By Raquel Segovia
Un grupo de científicos publicó una investigación en la que se detallan dos tipos de vacunas que combatirán la enfermedad y que podrán ser usados a partir del año 2018. Los efectos en los pacientes de los ensayos clínicos
Dos vacunas experimentales contra el virus del ébola demostraron ser una promesa para proteger en menos de un año contra la fiebre hemorrágica, de acuerdo con los resultados de un amplio ensayo clínico publicado el miércoles.
El reporte en el New England Journal of Medicine hace el primer recuento completo de un esfuerzo a gran escala para probar lo que podría ser la primera vacuna contra el ébola.
El brote del virus altamente contagioso y frecuentemente mortal dejo más de 11.000 fallecidos, principalmente en Liberia, Guinea y Sierra Leona cuando afectó al oeste de África desde finales de 2013 hasta 2016.
El brote mortal dejo más de 11.000 fallecidos (iStock) La fase II del estudio involucró a 1.500 personas en Monrovia, Liberia. Los participantes fueron elegidos al azar para recibir una o dos vacunas para ser probadas o un placebo.
La primera vacuna candidata fue el precursor rVSV-ZEBOV, inicialmente diseñado por científicos del gobierno de Canadá y ahora autorizado a Merck, Sharp y Dohme Corporation.
La segunda vacuna fue cAd3-EBOZ, desarrollada en conjunto por el instituto nacional para alergias y enfermedades infecciosas de Estados Unidos (NIAID) y GlaxoSmithKline
Después de un mes, 84% de los que recibieron el rVSV-ZEBOV desarrollaron un anticuerpo. El 80% siguieron estando protegidos durante un año.
El nuevo brote de ébola surgió en el Congo, de donde es originaria la enfermedad (OMS) En el caso de la otra vacuna candidata, cAd3-EBOZ, el 71% desarrolló una respuesta de anticuerpo, y 64% siguió teniendo la misma respuesta en un año, cuando el tratamiento terminó.
"Este tratamiento clínico ha aportado valiosa información que es esencial para continuar el desarrollo de estas dos vacunas candidatas y que también han demostrado que una investigación bien diseñada, éticamente sólida, se puede diseñar durante una epidemia", dijo Anthony Fauci, director de NIAID.
"Una vacuna segura y efectiva sería un complemento importante a las clásicas medidas de seguridad pública para controlar un inevitable brote de ébola", añadió.
A partir del 2018, las vacunas estarán disponibles (Shutterstock) Algunas personas que recibieron las vacunas experimentaron "de leves a moderados efectos que se resuelven, tales como dolor de cabeza, dolor muscular, estado febril y fatiga", dijo el reporte.
"Sobre todo, los investigadores dijeron que no se identificaron mayores preocupaciones de seguridad relacionadas con las vacunas. La mayoría de los asuntos médicos serios reportados durante el proceso fueron debido a la malaria".
La prueba fue conducida como parte de una colaboración de investigación clínica entre Estados Unidos y Liberia, conocida como Partnership for Research on Ebola Virus in Liberia (PREVAIL).
Unos 15 tipos de vacunas están siendo diseñadas en el mundo para prevenir esta enfermedad. Los expertos han dicho que las primeras vacunas podrían ser aprobadas para usarse en 2018, utilizando un proceso regulatorio expedito.
Con información AFP
By The Librarian
The patient who was recently admitted and isolated at Lacor hospital in Gulu district, after profuse bleeding, is suffering from a bleeding disorder, medical personnel have announced.
Dr Cyprian Opira, the executive director of the hospital says preliminary tests conducted on the patient indicate that she is suffering from lack of blood clotting factors, a condition that occurs when blood cannot clot properly.
The patient was isolated over the weekend after being transferred from Adjumani district with complaints of bleeding from her body openings.
Dr Opira says the hospital had a very difficult time managing the bleeding after the patient rejected blood transfusion on religious grounds. The patient is a follower of Jehovah's Witness, a religious group that bars its members from undertaking blood transfusions, donating or storing their own blood for transfusion.
Jehovah's Witnesses' literature teaches that rejecting transfusions is an indisputable religious stand and that those who respect life as a gift from God do not try to sustain life by taking in blood, even in an emergency. To them accepting transfusion is regarded as abandoning religious doctrines.
However, Dr Opira says that the bleeding has now subsided as the hospital waits for Ebola test results on samples taken to Uganda Virus Research Institute in Entebbe. He called for calm adding that health workers are well prepared to handle any emergency.
The Ebola fear came barely a month after the World Health Organisation-WHO confirmed an outbreak of Ebola in the Democratic Republic of Congo. According to the DRC health ministry, three people had died after testing positive to the virus in the remote Likati health district.
Ebola is a rare but deadly virus that causes bleeding inside and outside the body. It spreads through contact with the skin or bodily fluids of an infected animal or person. Medical experts say that the virus wrecks the immune system and damages almost every organ. To date, the disease has no cure.
The last outbreak killed more than 11,000 when the virus swept through the West African states of Liberia, Guinea and Sierra Leone Last year. It remains the most severe outbreak of Ebola since the discovery of Ebola viruses in 1976.
Uganda has witnessed five Ebola outbreaks over the past 14 years which have been quickly contained through a combination of epidemiological luck and a well-coordinated response system operating at several levels of the health service.
The most devastating was the first Ebola outbreak in Gulu in 2000 which infected 425 people and killed 224.
From Ugandan camp to Lowell, a Congolese family starts again
HARDSHIP, AND HOPE: Sendegeya Bayavuge joins his family, newly arrived from Africa, on the porch of their apartment in Lowell. With him, from left, are Dusenge Tuyishime, 14, Maria Uwimana, 16, Nyirakabanza Muhawenimana, 20, Sarah Nyiramana Bayavuge, 6, their mother, Vanisi Uzamukunda, 43, and Lea Nyiramahoro, 11. See a slide show at lowellsun.com. (SUN / JOHN LOVE)
LOWELL -- The Congolese family's home in Lowell is sparsely decorated, a sign of their recent arrival.
There's no art on the walls, no photos of smiling faces, no toys cluttering the floors. However, there is furniture and food and the basic necessities for a fresh start in the United States.
The family of seven -- father Sendegeya Bayavuge, 52, mother Vanisi Uzamukunda, 43, and five children ages 6-20 -- arrived in early February with help from a resettlement agency. The family had spent the past two decades at a Ugandan refugee camp after fleeing violent unrest in their native Democratic Republic of Congo, a country located in Central Africa.
"I see America as good and I can live in America," said Sendegeya through an
interpreter on a recent Monday afternoon, his hands clasped together as he sat in the corner of the living room. "I see here they have security. The way I was (living in Uganda), I was always in fear ... with security, I find everything good."
Maria Uwimana, 16, sat on a carpet beside her father in the family's second-floor apartment. Three of her siblings, sisters Nyirakabanza Muhawenimana, 20, and Lea Nyiramahoro, 11, and brother Dusenge Tuyishime, 14, sat across the room on a worn, cream-colored couch. The family's "princess," 6-year-old Sarah Nyiramana Bayavuge, nestled onto her mother's lap.
The family was spared in late January from President Donald Trump's executive order on immigration, which in part suspended the refugee admissions program for 120 days. Vanisi recalled hearing about the order as she waited with her family in a hotel for their flight to the United States.
"He said he don't want the guests. We lost the hope to come," Vanisi said through the interpreter. "After the situation changed and we came here, we were happy.
"I'm really grateful that they were not immediately impacted by the proposed suspension of the resettlement program," said Cheryl Hamilton, director of the Lowell site of the International Institute of New England, the agency assigned to resettle the family in partnership with the State Department.
A refugee is someone who has fled from his or her country and cannot return due to fears of persecution based on religion, race, nationality, political opinion or membership in a particular group and, according to the State Department. Since 1975 the U.S. has welcomed over 3 million refugees from all over the world. The city of Lowell has received 508 Iraqis, 220 Somalis, 31 Syrians, and 7 Sudanese during the 10-year period from 2007 through January 2017, according to federal data analyzed by the Associated Press.
Hamilton said about half of her staff's cases are refugees from the Congo since the U.S. government committed to accepting 25,000 of them across the country. According to 2009-2013 data on Massachusetts refugee arrivals from the Massachusetts Office for Refugees and Immigrants, 25 percent of 11,155 refugees admitted in the state hailed from the Congo.
Journey to a new life
It took over 24 hours for Sendegeya, Vanisi and their family to arrive in Lowell. They first stopped in Manchester, N.H. before being brought by resettlement workers to the light yellow multi-family house they now call home.
"In the beginning, we had a fear to fly because it was our first time to go on the airplane," Sendegeya said.
daughters, Maria Uwimana, 16. (SUN / JOHN LOVE)
"After that, we realized we are with other people."
He and Vanisi are bracing for the long road ahead. The children are still waiting to be enrolled in school, and the family as a whole is still struggling with having left their eldest child behind in Uganda. They don't have immediate family here and don't speak English. The language barrier, both parents admit, is a big obstacle they hope to overcome so they can have a better chance at finding jobs to support their family. Back in Uganda, Sendegeya worked as a farmer.
"I think that anybody moving into a new community, you're having to rebuild your entire social network and, with that, obviously being less familiar with employment opportunities or navigating transportation," Hamilton said. "Essentially, you are rebuilding every area of your life."
The United States allocates $925 per individual for the first three months in the country, according to Hamilton. Like with other refugee families the International Institute of New England helps resettle, Sendegeya and Vanisi's family will have access to integration services for the first year and be eligible to come back to the organization for employment services for up to a year and benefit from citizenship services for five years. Hamilton said her staff also offers other programs, such as after-school homework help.
"Obviously, the federal financial assistance is lean and it's remarkable the resiliency and the ability of families to navigate and overcome these challenges," Hamilton said.
Vanisi said her greatest fear involves protecting her children. Recently, while the children played outside, the mother said a neighbor warned them to be quiet and threatened to call the police.
"We saw our neighbor just coming to give us a warning without saying 'Good morning' or 'Welcome,'" Vanisi recalled. "It was just a warning -- 'Kids, shut up!'"
The incident was traumatic for Vanisi, who said her family now spends most of their time inside their home.
"In Uganda, it's different because in Uganda you can play and dance," she said. "Not that kind of warning."
There have been tiny victories through the murkiness. The family found a market with familiar foods and established a friendship with fellow Jehovah's Witnesses in nearby Chelmsford. Twice a week, members of the Kingdom Hall of Jehovah's Witnesses pick up the family for meetings.
The four daughters later walked up a flight of stairs to proudly show off their rooms -- Nyirakabanza and Maria in one, and Lea and Sarah in the other. Both rooms are bare except for neatly made twin-sized beds. In Lea and Sarah's closet, there are clothes and several pairs of shoes. The family's only son, Dusenge, has his own room. He remained quiet for the duration of the family's interview and smiled shyly when asked about his thoughts on his new home.
"Right now, what I like and what I have desired, I have found it," he said through the interpreter, his hands fiddling with a pale pink throw. "Everything is OK for me."
Ask the eldest, Nyirakabanza and Maria, what they dream of becoming someday and their eyes light up. Both said they hope to become nurses to help others.
"I'm happy here, but not yet," Nyirakabanza said, later clarifying that she is still sorting out her feelings about the family's new life in America. "I will be happy and confirm the happiness when I see my achievement. My goal is to go to school to continue my education -- to become someone self-sufficient. If I achieve that, I will be very very happy."
SWEET HOME: Sarah Nyiramana Bayavuge, 6, and her sister Lea Nyiramahoro, 11, in their new bedroom. The family was spared in late January from President Donald Trump's executive order on immigration. (SUN / JOHN LOVE)
By Bible Speaks
The set of Likasi is regional French-speaking, Democratic Republic of the Congo in Katanga province.. We welcomed 41 new baptized to an audience of about 2,000 people. Es el conjunto de Likasi expresión francesa regional, República Democrática del Congo, en la provincia de Katanga. Dimos la bienvenida a 41 nuevos bautizados a una audiencia de cerca de 2.000 personas. Merci beaucoup M!
By Bible Speaks
The set of Likasi is regional French-speaking, Democratic Republic of the Congo in Katanga province..
We welcomed 41 new baptized to an audience of about 2,000 people.
Es el conjunto de Likasi expresión francesa regional, República Democrática del Congo, en la provincia
de Katanga. Dimos la bienvenida a 41 nuevos bautizados a una audiencia de cerca de 2.000 personas.
Merci beaucoup M!
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