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Bible Speaks
Important article
The rise of bloodless medicine: how we treat those who cannot receive blood products for religious reasons or others
To Carlton D. Mill, Joseph J. Shatzel and Thomas G. Deloughery
The Discovery of the characterization of blood and the subsequent ability to infused blood safely has revolutionized medicine and has allowed people to survive lethal bleeding complications related to surgery, traumatic and non-traumatic injuries and even pregnancy.
While the transfusion has been beneficial to many patients, there are persons who, for religious or other reasons, reject blood products. This, in addition to the growing knowledge of certain risks associated with transfusion, has led to innovative approaches to the handling of blood loss.
As a result, among the health institutions, there is an increasing number of "Non-blood medicine" programmes that focus primarily on the best way to pay attention to patients who reject blood-derived products, the most common of which They're Jehovah's witnesses. Our group of medicine recently published our own best practices in several areas relevant to the care of these patients, including and intraoperative management, acute blood loss, trauma, pregnancy and malignancy.
Focus on non-blood
One of the central principles of medicine without bloodshed is to establish the individual beliefs of a person before he enters a situation related to blood loss, more commonly the surgery. However, establishing what a person is willing or unwilling to accept can be difficult. In Modern medical practice, human blood components (including red blood cells, platelets and coagulation proteins) are separated using laboratory techniques in what is known as "fractions" of blood, either of which can be transfused Of a particular patient needs
While there may be general rules regarding transfusion within a given religion, individual members may accept different fractions of blood depending on their own specific beliefs. However, some patients may have little or no knowledge of the blood fractions or the transfusion alternatives available to them. For this reason, patients in our institution can meet with a member of our medical program and an associate member of the religious community (as a representative of Jehovah's witnesses of the local hospital liaison committee) to help analyze the Transfusion. And their alternatives in detail and to help make decisions about acceptable treatments that align with the objectives of that patient.
We and others have suggested that this meeting be conducted in private with the patient only to avoid any coercion from third parties, including family members (patients may also opt to receive transfusions in private). This information on patient preferences can be used to facilitate discussions with surgical equipment, anesthesiology and in order to create a strategy for surgery and post-operative care.
Medical optimisation is also critical. Before surgery, we examine all patients to detect anemia and treat any underlying iron or vitamin deficiency that could be contributing to the decrease in the production of blood cells. If the patient is ready, we can also provide a hormone called erythropoietin (EPO) to help increase red blood cell levels, a treatment that is currently approved by the FDA for anaemic patients undergoing certain types of high-risk elective surgery. During surgery, a number of medical, surgical and anesthetic techniques may be implemented which relate to the reduction of bleeding.
What to do during the acute blood loss?
However, it remains particularly challenging when significant acute blood loss occurs, including bleeding that emerges after the operation, as well as traumatic and non-traumatic injuries. As the bleeding progresses, it decreases hemoglobin (a vital protein in red blood cells transporting oxygen to body tissues) and increases the risk of mortality.
Although the minimum haemoglobin required to maintain life is unclear, a Jehovah's witness study that rejected blood products after surgery showed that some patients were able to survive with the least amount of hemoglobin of 2.1-3.0 GRAMS PER DECILITER, which It's about 15-25 % normal. This suggests that even in the context of deep blood loss, transfusions are not the only option for survival.
In Case of acute bleeding, medical care providers must simultaneously search for what blood products they want and do not want to receive a patient (if not known or documented), provide resuscitation (such as intravenous fluids or other medicines to improve blood pressure) , reduce the additional blood loss (including the reduction of blood thinners and investigate the source of bleeding through surgery, images or endoscopy) and reverse any deterioration of the underlying coagulation (such as those related to the use of anticoagulants).
If a patient is willing, we can also provide other products to help stop bleeding, including medicines that inhibit the breakdown of the clot (such as acid, which is particularly beneficial in trauma-related bleeding) as well as derived coagulation factors Of the laboratory (as recombinant factor viia, which is produced from modified hamster cells containing the human coagulation gene, factor vii). Although it has not yet been approved by the FDA, our center also has experience in the use of "Oxygen-based oxygen transporters", which is an artificial blood substitute using hemoglobin derived from bovine animals to help transport the oxygen by the Body.
Pregnancy is another common area where non-blood drugs can provide benefits. Post-partum haemorrhage occurs in about 11 per cent of pregnancies worldwide, and is the main cause of maternal death worldwide, with studies showing that the risk of bleeding mortality is significantly higher for witnesses From Jehovah. Given the increased risk of complications, adequate prenatal preparation is essential at the beginning of pregnancy (generally under the care of an obstetrician familiar with high-risk pregnancies) to help ensure safe birth. This preparation includes appropriate advice, treatment of underlying anaemia and active collaboration with anesthesiologist and haematological.
If a post-partum haemorrhage occurs, it can be treated with intravenous fluids, medicines, repair of lacerations and manoeuvres such as uterine massage. If these measures do not control bleeding, invasive procedures or surgeries may be performed, including hysterectomy as a measure of last resort. Of particular interest, the recently completed woman study, which is a clinical trial of more than 20,000 women with postpartum haemorrhage, found that acid significantly reduces mortality, particularly if it is administered within 3 hours of the start of Bleeding.
Although not associated with the obvious loss of blood, cancer patients can also benefit significantly from drugs without bloodshed. Modern chemotherapy can have impressive healing rates in some cancers if it is aggressively treated. However, this often results in side effects related to chemotherapy, as well as severe anaemia and low platelets, of which patients may require significant transfusions to survive their treatment.
This poses a challenge to those who can potentially be cured but who reject blood products, because modifications to chemotherapy (such as dose reduction), although more tolerable, can compromise the ability to achieve healing; handling these Patients are extremely complex and should be considered on a case-by-Case basis. In patients for whom the purpose of treatment is not curative (i.e. a "palliative" Strategy), we recommend adjusting chemotherapy in such a way that it does not require transfusions. Notably, small studies and reports of patients with cancer of Jehovah's witnesses have reported a favourable response to treatment when they are supplemented by aggressive support measures and tolerance to the court of significant anaemia.
While patients who reject blood products may present significant ethical and medical challenges for health care providers, the risks of harm and death can be significantly reduced with careful and extensive planning. Ideally, this takes place long before an early event related to blood loss or anaemia, including elective surgery, pregnancy and cancer treatment. With progress in our understanding of anaemia and the advent of new medicines, surgical techniques and support support measures (including early detection and careful handling of anaemia), these patients can be successfully treated in a "No-spill" way Of blood ". although some of these novel treatments only have limited data to support their use, these interventions should still be considered if the bleeding threatening life persists despite other measures.
This study, treatment of individuals who cannot receive blood products for religious or other reasons, was recently published by Carlton D. Mill, Joseph J. Shatzel, Thomas G. Deloughery in the American Journal of hematology.
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