Health and Medicine
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Space Merchant reacted to a post in a topic:
South Korean Scientists conclude people cannot be infected twice with Covid19
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Isabella reacted to a post in a topic:
South Korean Scientists conclude people cannot be infected twice with Covid19
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"...the team used human blood stem cells and triggered mutations in the PARN gene that give rise to dyskeratosis congenita. These were then implanted into mice that were treated with the compounds, with the team finding the treatment boosted TERC, restored telomere length in the stem cells and had no ill effects on the rodents. “This provided the hope that this could become a clinical treatment,” says Nagpal. The team will now continue its work in an effort to prove these small molecules are a safe and effective way to apply the brakes to dyskeratosis congenita, other diseases, and possibly aging more broadly. “We envision these to be a new class of oral medicines that target stem cells throughout the body,” Agarwal says. “We expect restoring telomeres in stem cells will increase tissue regenerative capacity in the blood, lungs, and other organs affected in DC and other diseases.”
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Over the past century, the opinion that Vit-C can be used to treat cancer and viral infection has shown promises and controversies. There are cases where high dose Vit-C has shown benefits. In some cases, there have been no benefits. However, new knowledge regarding the pharmacokinetic properties of Vit-C, and recent preclinical studies, have revived interest in the utilization of high-dose Vit-C for cancer treatment [[132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145]]. Similar is the case of using IV Vit-C as antiviral, especially for the recent Covid19 [[146], [147], [148], [149], [150]]. It is believed that IV Vit-C has been particularly effective by inhibiting the production of cytokines storm due to Corvid19. Covid19 pneumonia is an extremely rapidly developing disease with a high mortality rate. The main pathogenesis is the acute lung injury that causes ARDS and death. Antioxidants should have a role in the management of these conditions. Appropriate clinical studies and reports demonstrate that a timely administration of high dose IV Vit-C improves the outcome of Covid19 infection. Additional studies detailing the use of IV Vit-C for the treatment of severe Covid19 infected pneumonia are definitively warranted. Covid19 may continue to happen in the future. Since the development of clinically active vaccines or antiviral drugs targeting specific diseases may take a long time to develop, the use of IV Vit-C as a universal agent for ARDS may have benefits behind Covid19. Additional clinical studies of the IV Vit-C and oral VC (such as liposomal-encapsulated VC) targeting other situations through different mechanisms are required to develop as soon as possible.
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My opinion is that you keep the correct levels of vitamin D in your body. Now a days, due to staying indoors, it is possible that you will develop the deficiency of vitamin D. Get this checked by your doctor and use the correct dose to stay healthy. Here are my notes: Daily 10 microgram or 400 IU/Day Lippincott’s Biochemistry Review 4th Edition. Page 388 Daily 5 mg of cholecalciferol or 200 IU of Vitamin D. However, 800 IU/Day is shown to reduce the incidence of osteoporotic fractures. 800 IU/Day recommended by the Institute of Medicine to maintain bone health. Frank deficiency is when the levels of 25-hydroxycholecalciferol (25OHD) is less than 20 ng/mL (50 mmol/L) ... No consensus that the oral vitamin D supplements are helpful Ergocalciferol from plants is called Vitamin D2 Cholecalciferol from the animal tissue is called Vitamin D3 7 deidro-cholesterol to (UV light) to cholecalciferol (D3) to 25 hydroxylase in liver to 25 OH D to -hydroxycholecalciferol 1-hydroxylase in kidney to 1,25 DiOH D3 Vitamin D Receptors are abbreviated to VDR in the notes. These are cytosolic receptors. ... Deficiency of vitamin D makes people more susceptible to respiratory tract infections. Vitamin D supplement can reduce these infections by 12% Keep in mind, this is for those who are deficient in this vitamin. If you are not deficient, then it will not make a difference. Because, you are already good. Evidence is not sufficient to say that vitamin D helps prevent respiratory infections. 2018 Study ... People with autoimmune diseases commonly have hypovitaminosis D What are cathelicidins? ... What are beta defensins? _... 2011 Study ... Activation of TLR and PAMPs on macrophages increases the production of 1, alpha hydroxylase and the VDR. This in turn causes more production of cathelicidine and beta defensins 4. Vitamin D also affects monocytes to reduce production of IL1, IL6, IL8, IL12, and TNF. Regulating the immune response. Vitamin D acts on the dendritic cells to inhibit/reduce their differentiation and maturation. It reduces their MHCII expression, co-stimulatory molecules like CD40, CD80, CD86, decreased production of IL-12 etc. 2013 Study ... Vitamin D improves immune system by helping produce cathelicidine and by helping modulate inflammatory cascade. Especially for the respiratory infections. It also helps produce NFk-B (nuclear factor kappa light chain for activated B cells.) ( Notes about the NFkB Helps with cytokine production and cell survival. NFk-B factor becomes active when T and B cell receptors become active. Its activation causes the gene expressions that allow T cell development, maturation, and proliferation. T and B cells have Vitamin D receptors that help them produce NFk-B ) Continuing the notes from the study: In pulmonary infections. Lung epithelial cells are able to convert inactive vitamin D to its active form. This active Vitamin D then helps produce cathelicidine. Which helps kill the pathogens. Vitamin D seems to favor TH2 and TH17 cell activation which is anti-inflammatory profile. Vitamin D seems to reduce the activation of TH1 cells which are pro inflammatory by their IFN-gamma action. A deficiency of vitamin D may dysregulate the inflammatory response of the body. Vitamin B also increases the IkBa. This leads to inhibition of NFkB. This helps reduce the production of IL6 and IL8 by inhibiting the production of NFkB.
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New Coronavirus (COVID-19) Drugs: Remdesivir, Tocilizumab (Actemra), and Leronlimab | New Coronavirus Treatment Remdesivir, Tocilizumab, and Leronlimab are new medications against Coronavirus (COVID-19) that are being explored. Besides hydroxychloroquine, these are other medications being investigated in the context of a clinical trial and some for compassionate use to treat coronavirus (COVID-19). Remdesivir, developed by Gilead Sciences Inc., is an investigational broad-spectrum antiviral treatment that was previously tested in humans with Ebola and had shown promise in animal models for treating Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS), which are caused by other coronaviruses. Currently Gilead Sciences has made Remdesivir available for coronavirus clinical trials and to more than 1800 people on a compassionate use basis. The hope is that the results from the phase 3 clinical trials will be available by the end of May, 2020. Tocilizumab is a monoclonal antibody that competitively inhibits the binding of interleukin-6 (IL-6) to its receptor (IL-6R). And by inhibiting the entire receptor complex, you block the signal to induce more inflammation from coronavirus. In a recent study from China, researchers noted Tocilizumab appears to be an effective treatment option in COVID‐19 patients with a risk of cytokine storms. And for these critically ill patients with elevated IL‐6, the repeated dose of the Tocilizumab is recommended. Leronlimab, made by the Canadian pharmaceutical Cytodyn, is a CCR5 reecptor inhibitor drug that was developed to treat HIV. The CCR5 receptor stands for “chemokine receptor type 5” and is expressed on t-cells, macrophages and even on breast and prostate cancer cells. By blocking this receptor, the principle is that you are block cytokines that direct cell movement for coronavirus (COVID-19). And by blocking the movement, you don’t bring immune cells to the site of infection from coronavirus (COVID-19), thus decreasing the risk of a cytokine storm. While there are many more drugs still in the pipeline to treatment COVID-19, these are the new drugs I feel have the most promise and are moving along to phase 3 clinical trials and onto the consumer market. - Dr. Yo.
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edvanguerra@hotmail.com reacted to a post in a topic:
New Coronavirus (2019-nCoV) Pandemic (aka WuFlu)
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edvanguerra@hotmail.com reacted to a post in a topic:
Daily emergency room baseline cases of pneumonia > 5000! in the US alone
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Isabella reacted to a post in a topic:
People collapsing on the streets of Seoul just as they did in Wuhan
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New Coronavirus (2019-nCoV) Pandemic (aka WuFlu)
Health and Medicine replied to TheWorldNewsOrg's topic in Topics
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So these were pictures of people collapsing were posted on social media in the past few days til yesterday (2/23) but no mention in the news. This makes sense because there is no freedom of press in South Korea and everything gets censored. (I know this first-hand because I worked in public radio for half a year in Seoul) The situation may be even worse than what is reported considering these photos are all in very recognizable spaces in Seoul, not Daegu. What's crazy is that I have personally walked by all of these areas shown on this pictures as have most people from Seoul. As of this moment only 31 people are confirmed to have SARS-COV-2 in Seoul. West Seoul Incheon Airport In the middle of Gangnam station area (One of the busiest areas in Seoul)
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In the US pneumonia is the most common cause of hospitalization other than giving birth. Pneumonia is the #1 most common reason for US children to be hospitalized. Half of all non-immunocompromised adults hospitalized for severe pneumonia in the US are younger adults (18-57 years of age). Half of the deaths from bacteremic pneumococcal pneumonia occur in people ages 18-64. Pneumonia is the most common cause of sepsis. After developing pneumonia, it often takes 6-8 weeks until a patient returns to their normal level of functioning and well being. Pneumonia can have longer term consequences. Children who survive pneumonia have increased risk for chronic lung diseases. Adults who survive pneumonia may have worsened exercise ability, cardiovascular disease, cognitive decline, and quality of life for months or years source
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I thought this was pretty interesting, as I was unaware of how common pneumonia really is: Given that there are about 1.86M emergency room encounters with pneumonia per year, consider that everyday over 5000 patients show up with pneumonia in US ERs. Goes to show how difficult it must be to separate signal from noise when it comes to early detection of COVID19 cases in the absence of mass testing! Further, I was unaware of how deadly regular non-COVID19 pneumonia already is, with 5%-10% of all hospitalized patients dying:
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Cruise operator bans Chinese nationals from its ships
Health and Medicine replied to Health and Medicine's topic in Topics
Welcome to the Royal Caribbean, Such a lovely place (such a lovely place) Such a lovely face. Plenty of room at the Royal Caribbean, Quarantines are here (this time of year) you can find it here Last thing I remember, I was Running for the door I had to find the passage back to the place I was before 'Relax' said the CDC man, 'We are programmed to receive. You can check out any time you like, But you can never leave!'
