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Depression study pinpoints genes that may trigger the condition


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Nearly 80 genes that could be linked to depression have been discovered by scientists.

The findings could help explain why some people may be at a higher risk of developing the condition, researchers say.

The study could also help researchers develop drugs to tackle mental ill-health, experts say.

Depression affects one in five people in the UK every year and is the leading cause of disability worldwide. Life events - such as trauma or stress - can contribute to its onset, but it is not clear why some people are more likely to develop the condition than others.

Scientists led by the University of Edinburgh analysed data from UK Biobank - a research resource containing health and genetic information for half a million people.

They scanned the genetic code of 300,000 people to identify areas of DNA that could be linked to depression.

Some of the pinpointed genes are known to be involved in the function of synapses, tiny connectors that allow brain cells to communicate with each other through electrical and chemical signals.

Read more: https://www.eurekalert.org/pub_releases/2018-04/uoe-dsp041318.php

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Forty-four genomic variants linked to major depression

Date:

April 26, 2018

Source:

University of North Carolina Health Care

Summary:

A new meta-analysis of more than 135,000 people with major depression and more than 344,000 controls has identified 44 genomic variants, or loci, that have a statistically significant association with depression.

A new meta-analysis of more than 135,000 people with major depression and more than 344,000 controls has identified 44 genomic variants, or loci, that have a statistically significant association with depression.

Of these 44 loci, 30 are newly discovered while 14 had been identified in previous studies. In addition, the study identified 153 significant genes, and found that major depression shared six loci that are also associated with schizophrenia.

Results from the multinational, genome-wide association study were published April 26 in Nature Genetics.

Read more: https://www.sciencedaily.com/releases/2018/04/180426130031.htm

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