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https://www.independent.co.uk/life-style/gadgets-and-tech/anti-ageing-reverse-treatment-telomeres-b1748067.html
Maybe I misunderstood but it appears they they “withheld” some oxygen for 90 minutes per day? Which seems counterintuitive to me.
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A Harvard team has discovered a set of small molecules capable of restoring telomere length in mice.By Health and Medicine
Hello guest! Please register or sign in (it's free) to view the hidden content. "...the team used human blood stem cells and triggered mutations in the PARN gene that give rise to dyskeratosis congenita. These were then implanted into mice that were treated with the compounds, with the team finding the treatment boosted TERC, restored telomere length in the stem cells and had no ill effects on the rodents.
“This provided the hope that this could become a clinical treatment,” says Nagpal.
The team will now continue its work in an effort to prove these small molecules are a safe and effective way to apply the brakes to dyskeratosis congenita, other diseases, and possibly aging more broadly.
“We envision these to be a new class of oral medicines that target stem cells throughout the body,” Agarwal says. “We expect restoring telomeres in stem cells will increase tissue regenerative capacity in the blood, lungs, and other organs affected in DC and other diseases.”
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By Guest Nicole
Thinking positively about aging might significantly reduce a person's risk of dementia, a new study has found—even for people with one of the strongest genetic risk factors.
Researchers from Yale University and the National Institute on Aging studied nearly 5,000 people aged 60 and older, over a period of four years, and discovered those who held negative beliefs about aging were far more likely to develop dementia.
The team assessed their test subjects' perceptions about various aspects of old age by asking how strongly they agreed or disagreed with statements like “The older I get, the more useless I feel."
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By Guest Nicole
Date:
August 2, 2017
Source:
Florida Atlantic University
Summary:
Restricting how much you eat without starving has been shown to robustly extend lifespan in more than 20 species of animals including primates. How this works is still unclear. A new study shows that it's not just what or how much you eat that matters. Smelling food in addition to consuming calories could influence the aging process. And, what's 'eating' you or more specifically your cells may provide clues to healthy aging.
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By Guest Nicole
CNN)You've likely heard that regular exercise can reduce the risk of chronic conditions such as heart disease, diabetes or osteoporosis.
But a growing body of research shows it may have another, more surprising effect: improving your sex life.
In men, regular exercise appears to be a natural Viagra: It's associated with a lower risk of erectile problems.
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By Guest Nicole
New research shows a major advantage for those who are highly active
Date:
May 10, 2017
Source:
Brigham Young University
Summary:
Despite their best efforts, no scientist has ever come close to stopping humans from aging. Even anti-aging creams can't stop Old Father Time. But new research reveals you may be able to slow one type of aging -- the kind that happens inside your cells. As long as you're willing to sweat.
Despite their best efforts, no scientist has ever come close to stopping humans from aging. Even anti-aging creams can't stop Old Father Time.
But new research from Brigham Young University reveals you may be able to slow one type of aging -- the kind that happens inside your cells. As long as you're willing to sweat.
"Just because you're 40, doesn't mean you're 40 years old biologically," Tucker said. "We all know people that seem younger than their actual age. The more physically active we are, the less biological aging takes place in our bodies."
The study, published in the medical journal Preventive Medicine, finds that people who have consistently high levels of physical activity have significantly longer telomeres than those who have sedentary lifestyles, as well as those who are moderately active.
Telomeres are the protein endcaps of our chromosomes. They're like our biological clock and they're extremely correlated with age; each time a cell replicates, we lose a tiny bit of the endcaps. Therefore, the older we get, the shorter our telomeres.
Exercise science professor Larry Tucker found adults with high physical activity levels have telomeres with a biological aging advantage of nine years over those who are sedentary, and a seven-year advantage compared to those who are moderately active. To be highly active, women had to engage in 30 minutes of jogging per day (40 minutes for men), five days a week.
"If you want to see a real difference in slowing your biological aging, it appears that a little exercise won't cut it," Tucker said. "You have to work out regularly at high levels."
Tucker analyzed data from 5,823 adults who participated in the CDC's National Health and Nutrition Examination Survey, one of the few indexes that includes telomere length values for study subjects. The index also includes data for 62 activities participants might have engaged in over a 30-day window, which Tucker analyzed to calculate levels of physical activity.
His study found the shortest telomeres came from sedentary people -- they had 140 base pairs of DNA less at the end of their telomeres than highly active folks. Surprisingly, he also found there was no significant difference in telomere length between those with low or moderate physical activity and the sedentary people.
Although the exact mechanism for how exercise preserves telomeres is unknown, Tucker said it may be tied to inflammation and oxidative stress. Previous studies have shown telomere length is closely related to those two factors and it is known that exercise can suppress inflammation and oxidative stress over time.
"We know that regular physical activity helps to reduce mortality and prolong life, and now we know part of that advantage may be due to the preservation of telomeres," Tucker said.
Story Source:
Materials provided by Brigham Young University. Note: Content may be edited for style and length.
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By Guest Nicole
The latest bedroom trend doesn’t have to do with a certain position or technique — and it’s not sexy at all.
The disturbing, nonconsensual trend is called “stealthing” and its rise is documented in a report by the Columbia Journal of Gender and Law.
Lead author Alexandra Brodsky argues that “stealthing,” when a man secretly removes his condom in the middle of sex, is a form of sexual assault and should be treated as such.
Even more troubling is the online community Brodsky uncovered, where men encourage other men to “stealth” their partners. These perpetrators — both gay and straight — believe it’s a man’s right to “spread one’s seed.”
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By Guest Nicole
Researchers are finding that your mental patterns could be harming your telomeres — essential parts of the cell’s DNA — and affecting your life and health. Nobel-winning scientist Elizabeth Blackburn and health psychologist Elissa Epel explain.
How can one person bask in the sunshine of good health, while another person looks old before her time? Humans have been asking this question for millennia, and recently, it’s becoming clearer and clearer to scientists that the differences between people’s rates of aging lie in the complex interactions among genes, social relationships, environments and lifestyles. Even though you are born with a particular set of genes, the way you live can influence how they express themselves. Some lifestyle factors may even turn genes on or shut them off.
Deep within the genetic heart of all our cells are telomeres, or repeating segments of noncoding DNA that live at the ends of the chromosomes. They form caps at the ends of the chromosomes and keep the genetic material from unraveling. Shortening with each cell division, they help determine how fast a cell ages. When they become too short, the cell stops dividing altogether. This isn’t the only reason a cell can become senescent — there are other stresses on cells we don’t yet understand very well — but short telomeres are one of the major reasons human cells grow old. We’ve devoted most of our careers to studying telomeres, and one extraordinary discovery from our labs (and seen at other labs) is that telomeres can actually lengthen.
What this means: aging is a dynamic process that could possibly be accelerated or slowed — and, in some aspects, even reversed. To an extent, it has surprised us and the rest of the scientific community that telomeres do not simply carry out the commands issued by your genetic code. Your telomeres are listening to you. The foods you eat, your response to challenges, the amount of exercise you get, and many other factors appear to influence your telomeres and can prevent premature aging at the cellular level. One of the keys to enjoying good health is simply doing your part to foster healthy cell renewal.
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By Guest Nicole
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By Guest Nicole
Misao Okawa – Misao Okawa of Osaka, Japan, was 117 when she died on April 1. She was the world's oldest person, according to Guinness World Records. She was born on March 5, 1898, and had three children. Her husband died in 1931. She kept in shape throughout much of her life; at 102, she said she did leg squats to keep healthy. She didn't start using a wheelchair until she turned 110.
(CNN)Go ahead lie about your age. It may be the very thing that helps you live a longer life.
If those fibbers truly believe that they are younger than what it says on their birth certificate, a new study shows they are among a group of people who have a lower death rate.
That's compared with those who felt their age or who even feel older than their years.
The new research letter is published in JAMA Internal Medicine online.
The study looked at data from from 6,489 people with an average age of 65.8 years who reported that they felt a little less than 10 years younger. What's interesting is most people in the study didn't feel like their actual age. Most said they felt about three years younger. Only a tiny percent, some 4.8%, felt at least a year older than their actual age.
When University College London researchers followed up on these people over the next eight years, the scientists found only a little over 14% of those who felt younger than their years had died. That was compared with the more than 24% of the people who reported feeling older or feeling their age who had died. Some 18% of the people who felt like their chronological age died in that same time period.
The researchers say they want to better understand what made the difference with this group.
"Possibilities include a broader set of health behaviors than we measured (such as maintaining a healthy weight and adherence to medical advice), and greater resilience, sense of mastery and will to live among those who feel younger than their age," the study concludes. "Self-perceived age has the potential to change, so interventions may be possible. Individuals who feel older than their actual age could be targeted with health messages promoting positive health behaviors and attitudes toward aging."
Dr. Sharon Bergquist, a physician and assistant professor of medicine at Emory University School of Medicine who specializes in healthy aging, isn't surprised by the results.
"Research is showing us that personality can so be tied to your destiny," Bergquist said.
New research into the link between personality and aging finds that there are two main traits that seem to help people live a longer life: conscientiousness and optimism.
People who have both traits may have more of a will to do the right thing to live a healthy lifestyle that can keep them healthy long into old age.
"Aging well can certainly become a self-fulfilling prophecy," she said.
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